产品编号:L99400165-001

产品描述:COX-2 (human) Polyclonal Antibody - 160107

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实验方法:

标记:

规格:1 ea

供应商:Biosense

价格(RMB):5425.00

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COX-2 (human) Polyclonal Antibody

Keywords: Prostaglandin H Synthase 2; PGHS-2; Cyclooxygenase 2

Antigen: human COX-2 amino acids 567-599 (SVPDPELIKTVTINASSSRSGLDDINPTVLLKE)1,2 · Host: rabbit · Cross-reactivity: (+) ovine and human COX-2; (-) COX-1 (all species) · Application: WB · COX-2 has been cloned from a variety of species including human, rat, and sheep and has a molecular weight of 72 kDa.2,3,4,5, COX-2 from these species are approximately 90% identical at the amino acid level, whereas the homology between COX-1 and COX-2 is only about 60%. Expression of COX-2 is regulated by growth factors, tumor promoters, bacterial endotoxin and cytokines, including IL-1β.6,7 COX-2 is present in human breast tumors but is not expressed in normal breast tissue.8

 
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2  Hla, T., Neilson, K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 89 7384-7388 (1992).
3  Kujubu, D.A., Fletcher, B.S., Varnum, B.C., et al. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266 12866-12872 (1991).
4  Yamagata, K., Andreasson, K.I., Kaufmann, W.E., et al. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids. Neuron 11 371-386 (1993).
5  Zhang, V., O’Sullivan, M., Hussain, H., et al. Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2. Biochem Biophys Res Commun 227 499-506 (1996).
6  Camacho, M., Godessart, N., Anton, R., et al. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. J Biol Chem 270 17279-17286 (1995).
7  Croxtall, J.D., Newman, S.P., Choudhury, Q., et al. The concerted regulation of cPLA2, COX2, and lipocortin 1 expression by IL-1β in A549 cells. Biochem Biophys Res Commun 220 491-495 (1996).
8  Parrett, M.L., Harris, R.E., Joarder, F.S., et al. Cyclooxygenase-2 gene expression in human breast cancer. Int J Oncol 10 503-507 (1997).