产品编号:PRO-512-2ug
产品描述:Recombinant Human Involucrin（Involucrin）
反应种属:
实验方法:
标记:
规格:2µg
供应商:Prospec
价格(RMB):2450.00
订购:
说明书:
Involucrin Human
Involucrin Human Recombinant
Catalog No. PRO-512
Synonyms:
Involucrin, IVL.
Introduction:
Involucrin is a soluble cytoplasmic protein precursor of the epidermal cornfied envelope that becomes cross-linked by transglutaminase during envelope assembly. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea which lacks a distinct cornfied layer. The protein is a useful marker of terminal differentiation. It is tightly linked to the onset of differentiation and first expressed in the immediate suprabasal layers of the epidermis.
Involucrin is mapped to 1q21 chromosome, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
Involucrin’s structure is composed of a conserved region of about 75 amino acid residues followed by two very variable length segments that contain glutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. The size of the protein varies from 285 residues (in dog) to 835 residues (in orangutan).
Description:
Involucrin Human Recombinant (aa 420-578) expressed in E.coli, shows a 41 kDa band on SDS-PAGE (Icluding GST tag).
The Involucrin is purified by proprietary chromatographic techniques.
Source:
Escherichia Coli.
Physical Appearance:
Sterile Filtered clear solution.
Formulation:
Involucrin in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Stability:
Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
Applications:
• ELISA
• Inhibition Assays
• Western Blotting
Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
