产品编号:PRO-285-250mg

产品描述:Aprotinin（Aprotinin）

反应种属:

实验方法:

标记:

规格:250mg

供应商:Prospec

价格(RMB):3780.00

订购:

说明书:

Aprotinin
Aprotinin
Catalog No. PRO-285

Synonyms:
Pancreatic trypsin inhibitor, Basic protease inhibitor, BPI, BPTI, Aprotinin, AP.

Introduction:
Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. Aprotinin is present in blood and in most tissues, with a high concentration in lung. Aprotinin inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins (e.g., CD11b).

Description:
Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids {C 284 H 432 N 84 O 79 S 7} arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512.

Source:
Bovine Lung

Physical Appearance:
Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation:
The protein (1mg/ml) was lyophilized with no additives.

Solubility:
It is recommended to reconstitute the lyophilized Aprotinin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability:
Lyophilized Aprotinin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Aprotinin should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Purity:
Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Unit Definition:
1 Unit corresponds to 1 biological kallikrein inhibitor unit (KIU)
1 TIU ≅1,300 KIU

Activity:
6,462 KIU (Kallikrein Inactivator Units) per mg, 4.97 TIU/mg.

Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.