产品编号:2243-1

产品描述:Alpha-Tubulin Phospho(pY272)antibody

反应种属:Human

实验方法:WB, ICC

标记:

规格:100ul

供应商:Epitomics

价格(RMB):2850.00

订购:

说明书:

Alpha-Tubulin Phospho(pY272)antibody

Cat.#: 2243-1

Rabbit Monoclonal Antibody

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. An essential component of microtubules, alpha-tubulin is also a multigene family in many species (1). Familial amyloidosis, British type, is an autosomal dominant disease characterized by progressive dementia, spastic paralysis and ataxia. The identity of the accumulating amyloid is not known, thus preventing the definitive classification of the disease. Findings suggest that the C-terminal fragments of both alpha- and beta-tubulin are closely associated to the amyloid deposits of familial amyloidosis, British type (2).

Recommended Applications

WB, ICC

Applications and Recommended Dilution Factors

WB: 1:25,000
ICC: 1:50 - 100

Species Reactivity

Human

Products Data

A. Western blot analysis on Jurkat cell lysates using anti-Phospho-Alpha-Tubulin (p272) RabMAb (cat. #2243-1), 1:50,000 dilution. Cells were either (A) untreated (B) treated with pervanadate.

  

  

Specificity

A phospho synthetic peptide corresponding to residues surrounding tyrosine 272 of human alpha-tubulin was used as an immunogen. This antibody detects alpha-tubulin phosphorylated at tyrosine 272.

Storage Buffer & Conditions

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Alternative Names

TUBA1B, Tubulin alpha-1B chain, Tubulin alpha-ubiquitous chain;Alpha-tubulin ubiquitous;Tubulin K-alpha-1

Description References

1. Cowan NJ et al. Mol Cell Biol 3(10):1738-45, 1983
2. Baumann MH, et al. Biochem Biophys Res Commun 219(6):238-42.