产品编号:2014-1
产品描述:Alpha-Synuclein Phospho(pS129)antibody
反应种属:Human
实验方法:WB
标记:
规格:100ul
供应商:Epitomics
价格(RMB):2850.00
订购:
说明书:
Cat.#: 2014-1
Alpha-Synuclein is expressed predominantly in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3).
WB
WB: 1:1000 - 10,000
Human, Mouse
A phosphor-specific peptide corresponding to residues surrounding Serine 129 of human Alpha-Synuclein was used as an immunogen. This antibody only detects alpha-synuclein phosphorylated on Ser129.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
SNCA, NACP, PARK1, Alpha-synuclein, Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor
1. Jakes R, et al. FEBS Lett. 345(1):27-32, 1994.
2. Fujiwara H, et al. Nat Cell Biol 4(2):160-4, 2002.
3. Shimura H, et al. Science 293(5528):263-9, 2001.
1. Qing H, Wong W, McGeer EG, et al, Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications ,Biochem Biophys Res Commun 387 (2009) 149-52
[Application: WB]
