产品编号:2028-1
产品描述:Alpha-1 Catenin antibody
反应种属:Human, Mouse, Rat
实验方法:WB, IHC, ICC, FC, IP
标记:
规格:100ul
供应商:Epitomics
价格(RMB):2500.00
订购:
说明书:
Cat.#: 2028-1
Cadherin and catenin compose cell adhesion complex and are indispensable for tight cell-cell adhesion. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, thus possibly contributing to cancer invasion and metastasis (1). At least three proteins (alpha, beta, and gamma catenin) comprise the cytoplasmic domain of the cadherin cell-cell adhesion complex. Data, with the reported structure of other catenin genes, suggest that vinculin and alpha-catenin generate a superfamily of proteins mediating membrane-cytoskeletal associations (2). Presenilin-1 (PS1) overexpression in human kidney cells enhances cell-cell adhesion and data show that PS1 incorporates into the cadherin/catenin adhesion system and regulates cell-cell adhesion. PS1 concentrates at intercellular contacts in epithelial tissue; in brain, it forms complexes with both E- and N-cadherin and concentrates at synaptic adhesions (3).
WB, IHC, ICC, FC, IP
WB: 1:50,000
IHC: 1:100 - 250
ICC: 1:100 - 250
FC: 1:50
IP: 1:50
Human, Mouse, Rat
A synthetic peptide corresponding to residues near the N-terminus of human α-1 catenin was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
CTNNA1, Catenin alpha-1, Cadherin-associated protein;Alpha E-catenin;NY-REN-13 antigen
1. Oda T, et al. Biochem Biophys 193(3):897-904, 1993
2. Rimm DL, et al. Biochem Biophys 203(3):1691-9, 1994
3. Georgakopoulos A, et al. Mol Cell 4(6):893-902, 1999
1. Lien WH, Gelfand VI, Vasioukhin V, α– E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic ,J. Cell Biol. 183 (2008) 989 - 997
[Application: IP]
