产品编号:1757-1

产品描述:Alpha-fetoprotein(C-term)antibody

反应种属:Human, Rat

实验方法:WB, IHC

标记:

规格:100ul

供应商:Epitomics

价格(RMB):2500.00

订购:

说明书:

Alpha-fetoprotein(C-term)antibody

Cat.#: 1757-1

Rabbit Polyclonal IgG Affinity Purified

Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver or yolk sac of fetal staged mammals. AFP synthesis is minimal after birth and a trace amount is expressed in the adult liver (1). AFP gene expression is regulated by the interactions between steroid hormone receptors and transcriptional factors in separate signal transduction pathways (2). AFP functions as a binding and transporting ligand and cell growth regulator. An elevated expression level of AFP has been implicated in colorectal, ovarian, pancreatic, testicular, and certain liver cancers. A high level of AFP is also seen in some diseases, such as hepatitis and colitis. AFP is used as a screening marker for fetal abnormalities in pregnant women, such as Down syndrome. Recently, AFP has been introduced as an anti-cancer drug-ligand carrier, transporting drugs to target tumor cells, increasing anti-tumor efficiency (3).

Recommended Applications

WB, IHC

Applications and Recommended Dilution Factors

WB: 1:5,000
IHC: 1:100-250

Species Reactivity

Human, Rat

Products Data

A. Western blot analysis on HepG2 cell lysate of using anti-AFP (C-term) Rabbit Polyclonal (cat. # 1757-1), dilution 1:50,000

B. Immunohistochemical analysis of paraffin-embedded human fetal liver using anti-AFP Rab pAb (cat. #1757-1).

  

Specificity

A synthetic peptide corresponding to residues in C-terminus of human AFP was used as an immunogen.

Storage Buffer & Conditions

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Alternative Names

AFP, HPAFP, Alpha-fetoprotein, Alpha-1-fetoprotein;Alpha-fetoglobulin

Description References

1. Wang XW, et al. World J Gastroenterol 7:345-351, 2001.
2. Chen H, et al. Crit Rev Eukaryot Gene Expr, 7:11-41, 1997.
3. Zheng AI, et al. CJC 22:108-111, 2003.