产品编号:2421-1

产品描述:Alpha B Crystallin antibody

反应种属:Human

实验方法:WB, IHC, ICC

标记:

规格:100ul

供应商:Epitomics

价格(RMB):2500.00

订购:

说明书:

Alpha B Crystallin antibody

Cat.#: 2421-1

Rabbit Monoclonal Antibody

Alpha B Crystallin, first identified as a structural component of the vertebrate eye lens, is expressed at high levels in lens and at lower levels in a number of other tissues, most notably cardiac and skeletal muscle, kidney, and brain (1). It is a major protein component of Rosenthal fibers (RF), which massively accumulate in the brains of patients suffering from Alexander's disease (2). The major phosphorylation site of Alpha B Crystallin in brains of patients with Alexander's disease or Alzheimer's disease as well as in aged controls is Serine 59 (3). Racemization, isomerization, and oxidation of Alpha B Crystallin are said to occur spontaneously in the aging process (4).

Recommended Applications

WB, IHC, ICC

Applications and Recommended Dilution Factors

WB: 1:500 - 2000
IHC: 1:100 - 250
ICC: 1:100 - 250

Species Reactivity

Human

Products Data

A.Western blot analysis on human heart cell lysate using anti-Alpha B Crystallin RabMAb (cat. # 2421-1), dilution 1:2000.

B. Immunohistochemical analysis of paraffin-embedded human muscle using anti- Alpha B Crystallin RabMAb (cat. #2421-1).

  

Specificity

A synthetic peptide corresponding to residues in human Alpha B Crystallin was used as an immunogen.

Storage Buffer & Conditions

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Alternative Names

CRYAB, CRYA2, Alpha-crystallin B chain, Renal carcinoma antigen NY-REN-27

Description References

1. Dubin RA, et al. Genomics 7(4):594-601, 1990
2. Iwaki A, et al. Neurosci Lett 140(1):89-92, 1992
3. Kato K, et al. J Neurochem 76(3):730-6, 2001
4. Fujii N, et al. Biochim Biophys Acta 204(2):157-63, 1994