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Alk/p80 antibody

产品编号:4204-1

产品描述:Alk/p80 antibody

反应种属:Human

实验方法:IHC

标记:

规格:100ul

供应商:Epitomics

价格(RMB):2050.00

订购:订购

说明书:

Alk/p80 antibody

Cat.#: 4204-1

Rabbit Monoclonal Antibody

Clone ID: SP8
Swiss Prot: Q9UM73
Mol Weight: 220kDa
Size: 100ul

Description

ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23 (1). In the predicted hybrid protein, the amino terminus of NPM is linked to the catalytic domain of ALK. Immunoblotting with anti-ALK antibody shows that ALK is highly expressed in the neonatal brain (2). Also expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas (3).

Recommended Applications

IHC

Applications and Recommended Dilution Factors

IHC: 1:100

Species Reactivity

Human


Products Data


A. Immunohistochemical staining of paraffin-embedded human anaplastic lymphoma stained with anti-Alk/p80 RabMAb (Cat. #4204-1)
  
  

Specificity

Recombinant protein corresponding to a region, which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript.

Storage Buffer & Conditions

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Alternative Names

ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase

Description References

1. Morris SW, et al. Science 263(5151):1281-4, 1994.
2. Iwahara T, et al. Oncogene 14(4):439-49, 1997.
3. Benharroch D, et al. Blood 91(6): 2076-84, 1998.