产品编号:2293-1
产品描述:Aldh1A1 antibody
反应种属:Human
实验方法:WB, IHC
标记:
规格:100ul
供应商:Epitomics
价格(RMB):2500.00
订购:
说明书:
Cat.#: 2293-1
Acetaldehyde dehydrogenase (ALDH) is the next enzyme after alcohol dehydrogenase in the major pathways of alcohol metabolism. Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3).
WB, IHC
WB: 1:1000
IHC: 1:100 - 250
Human
A synthetic peptide corresponding to residues in human ALdh1a1 was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
ADH1B, ADH2, Alcohol dehydrogenase 1B, Alcohol dehydrogenase subunit beta
1. Yoshida A, et al. Alcohol 2(1):103-6, 1985
2. Agarwal DP, et al. Enzyme 42(1):47-52, 1989
3. Collard F, et al. Biochimie 89(3):369-73, 2007
1. Zou D, Yoon HS, Anjomshoaa A, et al, Increased levels of active c-Src distinguish invasive from in situ lobular lesions ,Breast Cancer Res 11 (2009) R45
[Application: IHC]
