产品编号:5005-1

产品描述:Akt Substrates Ab Sampler Kit

反应种属:Human, Mouse, Rat

实验方法:WB, IHC, ICC, IP, FC

标记:

规格:7vials, 40ul each vial

供应商:Epitomics

价格(RMB):5350.00

订购:

说明书:

Akt Substrates Ab Sampler Kit

Cat.#: 5005-1

Description

AKT (Protein Kinase B) signaling pathway regulates a variety of biological processes including survival, proliferation, cell growth, cell motility and glycogen metabolism. Specifically, Akt1/PKBa is activated by various growth and survival factors (1). Phosphorylation on Thr308, Ser473 and Tyr474 is required for full activity. Akt1/PKBa inhibits apoptosis by phosphorylating and inactivating several targets, including caspase-9 (2).

Recommended Applications

WB, IHC, ICC, IP, FC

Species Reactivity

Human, Mouse, Rat

Products Data

A-G. Assay data using Akt Substrates Ab Sampler Kit (Cat# 5005-1) on various human samples.

  

Specificity

Human, Mouse, Rat

Components

Antibodies to: 14-3-3, Bad, Chk1, GSK3, IKK-a, p27 (Kip1), Raf

Storage Buffer & Conditions

Store at -20 C. 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Description References

1. Burgering, B.M. and P.J. Coffer. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599 2. Cardone, M.H., et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318