产品编号:1791-1

产品描述:AFP (C-term) antibody

反应种属:Human

实验方法:WB, IHC, IP

标记:

规格:100ul

供应商:Epitomics

价格(RMB):2500.00

订购:

说明书:

AFP (C-term) antibody

Cat.#: 1791-1

Rabbit Monoclonal Antibody

Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver or yolk sac of fetal staged mammals. AFP synthesis is minimal after birth and trace amount is expressed in the adult liver (1). AFP gene expression is regulated by the interactions between steroid hormone receptors and transcriptional factors in separate signal transduction pathways (2). AFP functions as a binding and transporting ligand and cell growth regulator. Elevated expression level of AFP has been implicated in colorectal, ovarian, pancreatic, testicular, and certain liver cancers. High levels of AFP is also seen in some diseases such as hepatitis and colitis. AFP is used as a screening marker for fetal abnormalities in pregnant women such as Down syndrome. Recently, AFP has been introduced as an anti-cancer drugs-ligand carrier, transporting drugs to target tumor cells, increasing anti-tumor efficiency (3).

Recommended Applications

WB, IHC, IP

Applications and Recommended Dilution Factors

WB: 1:1,000 - 2,000
IHC: 1:250-500
IP: 1:50

Species Reactivity

Human

Products Data

A. Western blot analysis on HepG2 membrane using anti-AFP RabMAb (cat. # 1791-1), dilution 1:50.000

B. Immunohistochemical staining of paraffin-embedded human fetal liver using anti-AFP RabMAb (cat. # 1791-1).

  

Specificity

A synthetic peptide corresponding to residues near the C-term of human AFP was used as an immunogen.

Storage Buffer & Conditions

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Alternative Names

AFP, HPAFP, Alpha-fetoprotein, Alpha-1-fetoprotein;Alpha-fetoglobulin

Description References

1. Wang XW, et al. World J Gastroenterol 7:345-351, 2001.
2. Chen H, et al Crit Rev Eukaryot Gene Expr, 7:11-41, 1997.
3. Zheng AI, et al. CJC 22:108-111, 2003.