产品编号:2123-1
产品描述:ACHR-beta (extracellular) Antibody
反应种属:Human, Mouse, Rat
实验方法:WB, ICC, FC
标记:
规格:100ul
供应商:Epitomics
价格(RMB):2500.00
订购:
说明书:
Cat.#: 2123-1
The nicotinic acetylcholine receptor controls electrical signaling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. The gate is a constricting hydrophobic girdle at the middle of the lipid bi-layer, formed by weak interactions between neighboring inner helices. When acetylcholine enters the ligand-binding domain, it triggers rotations of the protein chains on opposite sides of the entrance to the pore (1). The widespread distribution of the beta subunit suggests it may serve as a common subunit in different AChR combinations in various brain regions. Regulation of the expression of beta subunit appears to be relatively unrestrained, with an apparent excess of protein synthesized in the cytoplasm relative to that which ultimately arrives at functional targets in the plasma membrane (2).
WB, ICC, FC
WB: 1:1000 - 2000
ICC: 1:100
FC: 1:30
Human, Mouse, Rat
A synthetic peptide corresponding to residues in the extracellular region of human Acetylcholine receptor subunit beta was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
CHRNB1, ACHRB, CHRNB, Acetylcholine receptor subunit beta
1. Miyazawa A, et al. Nature 423(6943):949-55, 2003
2. Hill JA, et al. J Neurosci 13: 1551-68, 1993
