产品编号:1768-1
产品描述:ACC1(Acetyl CoA Carboxylase 1)antibody
反应种属:Human, Mouse, Rat
实验方法:WB, IHC
标记:
规格:100ul
供应商:Epitomics
价格(RMB):2500.00
订购:
说明书:
Cat.#: 1768-1
Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).
WB, IHC
WB: 1:500 - 2000
IHC: 1:50 - 100
Human, Mouse, Rat
A synthetic peptide corresponding to residues in the human Acetyl-CoA carboxylase 1 was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
ACACA, ACAC, ACC1, ACCA, Biotin carboxylase, ACC-alpha
1. Jianqiang M, et al. PNAS 100:7515-7520, 2003.
2. Girad J, et al. The FASEB Journal 8:36-42, 1994.
3. Wakil SJ, et al. Annu Rev Biochem 52:537-539
4. Abu-Elheiga L, et al. Science 291: 2613-2616. 2001.
1. Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, et al, Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin ,FASEB J 23 (2009) 241-258
[Application: WB]
2. Ota S, Horigome K, Ishii T, et al, Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism ,Biochem Biophys Res Commun 388 (2009) 311-316
[Application: WB]
