产品编号:2504-1
产品描述:ACE(membrane form specific)antibody
反应种属:Human, Mouse
实验方法:WB, FC
标记:
规格:100ul
供应商:Epitomics
价格(RMB):2500.00
订购:
说明书:
Cat.#: 2504-1
Angiotensin-converting enzyme (ACE) is a zinc-containing dipeptidyl carboxypeptidase anchored in the plasma membrane with a carboxy-terminal hydrophobic domain (1, 2). ACE has a critical role in cardiovascular function because it catalyses the conversion of angiotensin I to the physiologically active vasopressor octapeptide angiotensin II, which controls fluid-electrolyte balance and systemic blood pressure (3, 4). Inhibitors of ACE are a first line of therapy for hypertension, heart failure, myocardial infarction and diabetic nephropathy (4). ACE also plays a critical role in the circulating or endocrine renin-angiotensin system (RAS) as well as the local regulation that exists in tissues such as the myocardium and skeletal muscle (5).
WB, IHC, FC
WB: 1:1000 - 10,000
IHC: 1:100 - 250
FC: 1:30
Human, Mouse
Products Data
A synthetic peptide corresponding to residues on the C-terminus of human ACE was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
ACE, DCP, DCP1, Angiotensin-converting enzyme, soluble form, Dipeptidyl carboxypeptidase I;Kininase II
1. Ehlers MR, et al. Proc Natl Acad Sci U S A. 86(20):7741-5,1989
2. Sugimura K, et al. Biochem Biophys Res Commun. 247(2):466-72, 1998
3. Rieder MJ, et al. Nat Genet. 22(1):59-62, 1999
4. Natesh R, et al. Nature. 421(6922):551-4, 2003
5. Natesh R, et al. Biochemistry. 43(27):8718-24, 2004
