产品编号:2305-1
产品描述:4-1BBL antibody
反应种属:Human
实验方法:WB, IHC, ICC, IP
标记:
规格:100ul
供应商:Epitomics
价格(RMB):2500.00
订购:
说明书:
Cat.#: 2305-1
4-1BB was originally described as a cDNA expressed by activated murine T cells and subsequently demonstrated to encode a member of the tumor necrosis factor receptor family of integral membrane proteins. Recently, a murine ligand for 4-1BB (mu4-1BB-L) was cloned and demonstrated to be a member of an emerging family of ligands with structural homology to tumor necrosis factor. Both monoclonal antibody to hu4-1BB and cells transfected with hu4-1BB-L induced a strong proliferative response in mitogen co-stimulated primary T cells. In contrast, ligation of 4-1BB on T cell clones enhanced activation-induced cell death when triggered by engagement of the TCR/CD3 complex. (1). To reject tumors, T cells must overcome poor tumor immunogenicity and an adverse tumor microenvironment. It has been shown that primary human T cells expressing CD80 and 4-1BBL vigorously respond to tumor cells lacking costimulatory ligands and provoke potent rejection of large, systemic tumors in immunodeficient mice (2).
WB, IHC, ICC, IP
WB: 1:500
IHC: 1:100
ICC: 1:100
IP: 1:40
Human
A synthetic peptide corresponding to residues near the N-terminus of human 4-1BBL was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
TNFSF9, Tumor necrosis factor ligand superfamily member 9, 4-1BB ligand
1. Alderson MR, et al. Eur J Immunol 24(9):2219-27, 1994
2. Steohan MT, et al. Nat Med 13(12):1440-9, 2007
